All posts by Dave

31Jul/16

Thought Of The Day – AMPK, Pulmonary Vasculature & RV

Today’s thought stems from a quote I found reading Metabolic Regulation: A Human Perspective by Keith N. Frayn. This is one of my new favorite books… Quote: “AMPK senses energy status of the cell: when there is a drain on ATP, AMP rises and the AMPK is activated, leading in turn to inhibition of ATP utilizing pathways (particularly biosynthetic pathways) and activation of ATP-generating pathways (glucose uptake, glycolysis, fatty acid oxidation).” Thought: AMPK (5′ AMP-activated protein kinase) activation in some form, either via dietary means, or as a drug target, would seem to be a good idea for the pulmonary vasculature as it would potentially prevent proliferation of PASMC’s and PAEC’s, and perhaps even adventitial fibroblasts (because of the “preventing biosynthetic pathway” feature stated above).… Read More...
20Jun/16

SearchingPHorACure.com, Now Live!

Welcome! This blog is a personal project of mine… one with the sole aim of finding a cure for Pulmonary Hypertension, and Cardiopulmonary diseases at large. By writing about the science of cardiopulmonary vascular diseases, the latest news in the field, new theories and ideas, as well as musings about nutrition and health/lifestyle choices, it is my hope that this website and its content may somehow help in fostering creativity, innovation, knowledge, and awareness in the Pulmonary Hypertension community, and ultimately help bring the prospect of a cure one step closer… This blog is both technical and non-technical and is written for audiences of scientists/medical professionals as well as average readers.… Read More...