12Aug/16

“Role Of T-Regulatory Cells In Immune Modulation” – A Synopsis

Below is a video and synopsis of the talk “Role Of T-Regulatory Cells In Immune Modulation” by Dr. Maria Roncarolo at the Vera Moulton Wall Center for Pulmonary Vascular Disease: Summary Standard treatment of immune mediated diseases involves anti-inflammatory and immunosuppressive drugs. By doing this, you downregulate the physiological mechanism to counteract inflammation and adaptive immune responses to self-antigens. Almost all immunosuppressive drugs block T-regulatory cell induction and function. Tolerance is not a lack of immune response, it is just a different type of immune response that the immune system puts in place when we want to tolerize an antigen (self antigen or de novo antigens) There are no drugs out there that induce tolerance to a specific antigen that we want to down-regulate Overall goal: tone down specific immune responses without completely suppressing immunity.… Read More...
04Aug/16

“Novel Insights Into Lung Autoimmunity Through Research In Rare Mendelian Diseases” – A Synopsis

This is a video by Dr. Anthony Shum from an excellent series of talks by the Vera Moulton Wall Center for Pulmonary Vascular Disease (a brief summary of which is below): Summary Exome sequencing (similar to what 23andMe does) can provide insight into rare Mendelian diseases. Specifically, Dr. Shum has used this to analyze patients with autoimmune interstitial lung disease patients (typically patients who present at a young age, have pulmonary hemorrhage, arthritis, and presence of the autoantibodies ANCA and ANA) and has found that they all contain a mutation in the COPA gene, which was predicted to be damaging. COPA is ubiquitously expressed, and enables protein transport between the Golgi Apparatus and the ER.… Read More...