24Aug/16

“Fatty acid metabolism in pulmonary arterial hypertension: role in right ventricular dysfunction and hypertrophy” – A Review

In the below I will be referencing and discussing quotes from the paper “Fatty acid metabolism in pulmonary arterial hypertension: role in right ventricular dysfunction and hypertrophy” by M. Talati. Basically, I’m distilling the key points that I’ve learned, summarizing them, and including any thoughts I may have. Overall it appears that the running thread through this paper is the following: Can metabolic syndrome or insulin resistance in PH cause RV dysfunction? Or is the dysfunction a result of PH? In sum, there is a dysregulation in fatty acid oxidation and glucose oxidation, with increased intracellular lipid accumulation, and an overall switch to glycolysis in the heart.… Read More...
31Jul/16

Thought Of The Day – AMPK, Pulmonary Vasculature & RV

Today’s thought stems from a quote I found reading Metabolic Regulation: A Human Perspective by Keith N. Frayn. This is one of my new favorite books… Quote: “AMPK senses energy status of the cell: when there is a drain on ATP, AMP rises and the AMPK is activated, leading in turn to inhibition of ATP utilizing pathways (particularly biosynthetic pathways) and activation of ATP-generating pathways (glucose uptake, glycolysis, fatty acid oxidation).” Thought: AMPK (5′ AMP-activated protein kinase) activation in some form, either via dietary means, or as a drug target, would seem to be a good idea for the pulmonary vasculature as it would potentially prevent proliferation of PASMC’s and PAEC’s, and perhaps even adventitial fibroblasts (because of the “preventing biosynthetic pathway” feature stated above).… Read More...